76349-07-0

Basic information

• Product Name: N-(2-Hydroxypyridin-3-yl)acetamide
• Synonyms: N-(2-Hydroxypyridin-3-yl)acetamide;N-(2-Oxo-1,2-dihydropyridin-3-yl)acetaMide
• CAS NO: 76349-07-0
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15062
• Mol File: 76349-07-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 496.5°C at 760 mmHg
• Flash Point: 246.6°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 5.36E-10mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-Hydroxypyridin-3-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Hydroxypyridin-3-yl)acetamide(76349-07-0)
• EPA Substance Registry System: N-(2-Hydroxypyridin-3-yl)acetamide(76349-07-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 76349-07-0(Hazardous Substances Data)

Usage

General Description

N-(2-Hydroxypyridin-3-yl)acetamide, also known as 3-Pyridylglycerol, is a chemical compound with the chemical formula C7H8N2O2. It is a derivative of pyridine and acetamide, containing a hydroxyl group on the 2-position of the pyridine ring. N-(2-Hydroxypyridin-3-yl)acetamide is commonly used in the synthesis of pharmaceuticals and agrochemicals, due to its potential as a building block for drug molecules. It may also have applications in the development of novel materials and functional molecules. Additionally, N-(2-Hydroxypyridin-3-yl)acetamide may have biological activities and therapeutic potential, which makes it an important target for further research and development in the fields of medicinal chemistry and drug discovery.

InChI:InChI=1/C7H8N2O2/c1-5(10)9-6-3-2-4-8-7(6)11/h2-4H,1H3,(H,8,11)(H,9,10)

Upstream product

• 33630-99-8 2-hydroxy-3-aminopyridine 
• 108-24-7 acetic anhydride 
• 6332-56-5 2-hydroxy-3-nitropyridine 
• 33630-99-8 3-amino-2-pyridone 
• 6332-56-5 3-nitropyridone 
• 142-08-5 2-Pyridone 

Relevant articles and documents

A VERSATILE LIGAND FOR PALLADIUM-CATALYZED META-C-H FUNCTIONALIZATIONS

A class of mono-protected 3-amino-2- hydroxypyridine (MPAHP) ligands that enable the meta- C-H arylation of anilines, phenols, phenylacetic acids, and biologically relevant heterocyclic compounds using norbornene as a transient mediator is disclosed. The applicability of this meta-arylation methodology in the pharmaceutical industry is illustrated for heteroaryl substrates and heteroaryl iodide coupling partners, a feat made possible by using the MPAHP ligand. The enabling nature of MPAHP ligands to achieve other meta-C-H functionalization processes is also illustrated by the development of a meta-C-H amination reaction and a meta-C-H alkynylation reaction.

Pyridones as potential antitumor agents II: 4-pyridones and bioisosteres of 3-acetoxy-2-pyridone

Pyridone structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity. An amino group can be substituted for the 3-hydroxyl function with retention of activity. A sulfur, but not an amino function, can replace the lactam oxygen in the 2-position. Relocation of the lactam oxygen from the 2- to the 4-position in the pyridine ring also produces active pyridones, including 2-methyl-3-acetoxy-4-pyridone. This compound, which has a T/C value of 179%, is the most active material discovered thus far in the pyridone studies.