76349-08-1

Basic information

• Product Name: 1-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)urea
• CAS NO: 76349-08-1
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.1653
• Mol File: 76349-08-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 387.1°C at 760 mmHg
• Flash Point: 185.4°C
• Density: 1.28g/cm³
• Vapor Pressure: 3.38E-06mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 1-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)urea(76349-08-1)
• EPA Substance Registry System: 1-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)urea(76349-08-1)

Safety Data

• Hazardous Substances Data: 76349-08-1(Hazardous Substances Data)

Usage

Chemical class

Ureas

Derivatives

Dihydropyridine and urea

Potential biological activities

Anti-inflammatory, analgesic, and anti-nociceptive properties

Potential therapeutic applications

Pain management and inflammation, neurodegenerative disorders such as Alzheimer's disease

Potential as a cholinesterase inhibitor

Yes

Further research needed

Yes

Upstream product

• 6332-56-5 3-nitropyridone 
• 142-08-5 2-Pyridone 
• 33630-99-8 3-amino-2-pyridone 
• 624-83-9 methyl isocyanate 

Relevant articles and documents

Pyridones as potential antitumor agents II: 4-pyridones and bioisosteres of 3-acetoxy-2-pyridone

Pyridone structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity. An amino group can be substituted for the 3-hydroxyl function with retention of activity. A sulfur, but not an amino function, can replace the lactam oxygen in the 2-position. Relocation of the lactam oxygen from the 2- to the 4-position in the pyridine ring also produces active pyridones, including 2-methyl-3-acetoxy-4-pyridone. This compound, which has a T/C value of 179%, is the most active material discovered thus far in the pyridone studies.