76350-18-0

Upstream product

• 35453-19-1 2,4,6-triiodo-5-aminoisophthalic acid 
• 40976-89-4 2,4,6-triiodo-5-(methylamino)isophthalic acid 

Downstream Products

• 99139-37-4 N,N'-bis-allyl 5-(methylamino)-2,4,6-triiodoisophthaldiamide 
• 122731-71-9 5-Methylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxy-propyl) monoamide chloride 
• 76350-17-9 5-(N-methoxyacetyl-N-methylamino)-2,4,6-triiodoisophthalic acid dichloride 
• 869339-46-8 N,N-bis-[2-(2-aminoacetylamino)ethyl]-5-(methylamino)-2,4,6-triiodoisophthalic acid amide 
• 752253-28-4 2,4,6-Triiodo-5-{methyl[2-(2,2,2-trifluoroacetylamino)-acetyl]amino}-isophthalic acid dichloride 
• 78649-32-8 [(acetoxyacetyl)-N-methylamino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid chloride 
• 869339-45-7 N,N-bis-[2-tert-butoxycarbonylaminoacetyl-(2-aminoethyl)]-5-(methylamino)-2,4,6-triiodoisophthalic acid amide 
• 869339-30-0 N,N-bis-(2-aminoethyl)-5-(methylamino)-2,4,6-triiodoisophthalic acid amide 

Relevant academic research and scientific papers

preparation method of contrast agent

The present invention relates to a method for producing a contrast medium with high purity and high efficiency, and since no methyl iodide and the like are used in a production process, no salt is generated or only a very small amount thereof is generated, and a high purity and high efficiency contrast medium can be produced without complicated purification and washing steps. In addition, a small amount of salt can be easily removed by washing with water.COPYRIGHT KIPO 2018

CONTRAST AGENTS

Compounds of formula (I) RA—CO—N(R2)—(CR12)n—N(R5)—RB and salts or optical active isomers thereof, wherein each R1 independently are the same or different and denotes

CONTRAST AGENTS

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I) and salts or optical active isomers thereof, wherein each R1 independently are the same or different and denotes a hydrogen atom or a C1 to C4 straight or branched alkyl group which is optionally substituted by 1 to 4 - OH groups; each of R2 independently are the same or different and denote a hydrogen atom or a C1 to C4 straight or branched alkyl group; each R3 independently are the same or different and denotes a hydrogen atom or a C1 to C4 straight or branched alkyl group which is optionally substituted by 1 to 4 - OH groups; each R4 independently are the same or different and denote C1 to C6 straight or branched alkyl moieties substituted by up to 6 -OH groups; and each R5 independently are the same or different and denote C1 to C6 straight or branched alkyl moieties substituted by up to 6 -OH groups; and X denotes a straight chain alkylene moiety with 3 to 10 carbon atoms, a 1,4- cyclohexylene group, or X together with the adjacent -NR1 groups forms a 1,4- piperazine group or a 4-aminopiperidine group. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

CONTRAST AGENTS

Compounds of formula (I) RA-CO-N(R2)-(CR12)n-N(R5)-RB and salts or optical active isomers thereof, wherein each R1 independently are the same or different and denotes

Carboxamide non-ionic contrast media

Novel triiodo 5-aminoisophthaldiamides are provided, where the amino and one of the amide nitrogens are substituted. The compounds have at least two hydroxyl groups and are found to provide low viscosity and osmolality. Procedures for preparing the compounds are provided.

Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these

Compounds for use in non-ionic X-ray contrasting materials having the formula STR1 in which (H0)2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, R is hydrogen or methyl, and R1 is an alkyl residue with 1 to 5 carbon atoms. These compounds possess high water-solubility as well as excellent stability against hydrolysis. Methods for preparation and use of the compounds are also disclosed.

Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media

Novel intermediates for non-ionic polyiodo amino-substituted benzenepolyamides having polyol substituents on the amide nitrogens are provided which are 5-amino-6-hydroxy-1,3-dioxepanes. The compounds provide an economic and efficient route to novel contrast media having excellent chemical and physiological properties. Also provided are methods for preparing the subject compounds.