76351-84-3 Usage
Chemical compound
2-Amino-N-(8-(p-chlorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide
Structure
Complex and specific
Derivative
Pyrimidinecarboxamide
Groups attached
Methoxy, p-chlorobenzyl, amino, 3-beta-nortropanyl
Potential applications
Pharmaceutical research and drug development
Properties
Unique structure, potential biological activity
Potential uses
Synthesis of new drugs, lead compound for further studies
Check Digit Verification of cas no
The CAS Registry Mumber 76351-84-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,3,5 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 76351-84:
(7*7)+(6*6)+(5*3)+(4*5)+(3*1)+(2*8)+(1*4)=143
143 % 10 = 3
So 76351-84-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H24ClN5O2/c1-28-19-17(10-23-20(22)25-19)18(27)24-14-8-15-6-7-16(9-14)26(15)11-12-2-4-13(21)5-3-12/h2-5,10,14-16H,6-9,11H2,1H3,(H,24,27)(H2,22,23,25)
76351-84-3Relevant academic research and scientific papers
Studies on the neuroleptic benzamides. III - Synthesis and antidopaminergic properties of new 3-nortropane derivatives
Dostert,Imbert,Langlois,et al.
, p. 105 - 110 (2007/10/02)
Various benzamides prepared from 4-alkoxy pyrimidine 5-carboxylic acids and 3-amino nortropane derivatives have been tested for their potential antipsychotic activity. Two compounds exhibited pharamacological activity equivalent to that of haloperidol but had lower toxicity and lower potency to induced catalepsy. Antidopaminergic activity is observed mainly in compounds in which the nortropane ring is substituted in the equatorial position, having a benzyl substituent on the basic nitrogen. The influence of electron attractor or donor substituents carried by the benzyl ring has been evaluated. Some aspects of structure-activity relationships are discussed.
