76362-28-2

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE is used as an intermediate in the synthesis of Alfuzosin, a medication that serves as a potential α1-adrenoceptor antagonist. Its role in the synthesis process is crucial for the development of this drug, which is used to treat various conditions related to prostate enlargement and other related urinary issues.
Used in Chemical Research:
As a chemical compound with unique structural features, N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE can also be utilized in chemical research for the exploration of new drug candidates, understanding its reactivity, and investigating its potential interactions with various biological targets. This can lead to the discovery of new therapeutic agents and a better understanding of its pharmacological properties.

InChI:InChI=1/C14H17N5O2/c1-19(6-4-5-15)14-17-10-8-12(21-3)11(20-2)7-9(10)13(16)18-14/h7-8H,4,6H2,1-3H3,(H2,16,17,18)

Upstream product

• 693-05-0 N-(2-cyanoethyl)-N-methylamine 
• 23680-84-4 2-chloro-6,7-dimethoxyquinazolin-4-amine 
• 132900-51-7 4-amino-2-chloro-6,7-dimethoxyquinazoline hydrochloride 

Downstream Products

• 76362-29-3 N¹-methyl-N¹-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine 

Relevant academic research and scientific papers

PROCESS FOR PREPARING ALFUZOSIN

Processes for preparing alfuzosin and pharmaceutically acceptable salts, solvates, hydrates thereof are disclosed. The present invention also discloses processes for preparation of anhydrous alfuzosin hydrochloride having substantially free from other pseudopolymorphic crystalline forms particularly dihydrate form of alfuzosin hydrochloride.

AN IMPROVED PROCESS FOR THE PREPARATION OF ALFUZOSIN HYDROCHLORIDE

The present invention relates to an improved process for the preparation of Alfuzosin hydrochloride of formula (I) comprising a step of reacting compound of formula (IV) with compound of formula (V) in presence of aprotic solvent to obtain compound of formula (III) which is a useful intermediate for synthesis of Alfuzosin hydrochloride of formula (I).

PROCESS FOR THE PREPARATION OF ALFUZOSIN

The present invention relates to an improved process for the preparation of N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydrofuran-2-carboxamide of Formula (I).

PROCESSES FOR THE PREPARATION OF ALFUZOSIN

The invention relates to processes for the preparation of alfuzosin or pharmaceutically acceptable salts thereof in high purity. More particularly, it relates to the preparation of pure crystalline alfuzosin base. The invention also relates to pharmaceutical compositions that include the pure alfuzosin or a pharmaceutically acceptable salt thereof.

PROCESS FOR THE PREPARATION OF ALFUZOSIN

The present invention relates to a simple process for the preparation of alfuzosin, it's bases and its pharmaceutically acceptable salts thereof.

PROCESSES FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF AND NOVEL CRYSTALLINE FORMS OF ALFUZOSIN

The present invention provides novel crystalline forms of a.lfuzosin and alfuzosin hydrochloride and processes for their preparation. Also provided are pharmaceutical compositions containing the new crystalline forms.

4-Amino-6,7-dimethoxyquinazol-2-yl alkylenediamines

Alkylenediamine amides corresponding to the general formula (I) STR1 in which R1 and R2 each represent, independently of one another, a hydrogen atom, an alkyl having 1 to 4 carbon atoms or the benzyl radical, n is equal to 2, 3 or 4 and R represents either a cycloalkyl radical having 3 to 6 carbon atoms, or a radical STR2 in which m is 0, 1 or 2, STR3 in which m is 0, 1 or 2 and p is 0, 1 or 2, and also their addition salts with pharmaceutically acceptable acids. These compounds may be prepared by reacting an aminoamide STR4 with a 4-amino-2-halogeno-6,7-dimethoxyquinazoline (II). The compounds are useful in treating cardiovascular disorders, and pharmaceutical compositions containing the compounds are also claimed.