76364-60-8Relevant academic research and scientific papers
6-Amidinopenicillanic acid derivatives including the radical of a β-lactamase inhibitor
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, (2008/06/13)
The present invention relates to hitherto unknown compounds of the general formula I: STR1 in which R1 stands for a five- to ten-membered azacycloalkyl or azabicycloalkyl residue attached via the nitrogen atom and optionally being substituted by one or two, the same or different, lower alkyl groups; R2 represents a hydrogen atom or a lower alkyl, aryl, or aralkyl radical; and A represents a radical of a β-lactamase inhibitor containing a β-lactam ring as well as a carboxy group, A being connected via the carboxy group. The present compounds are useful in the treatment of bacterial infections. The new compounds are in particular strongly active against β-lactamase producing bacteria.
