76368-25-7Relevant academic research and scientific papers
ASYMMETRIC SYNTHESIS OF β-LACTAMS. II. HIGHLY EFFECTIVE ASYMMETRIC INDUCTION BY MEANS OF "TITANIUM TEMPLATE"
Ojima, Iwao,Inaba, Shin-ichi
, p. 2081 - 2084 (1980)
The reaction of dimethylketene methyl trimethylsilyl acetal with the Schiff bases of chiral α-amino esters in the presence of titanium tetrachloride gave the corresponding β-lactams with extremely high stereoselectivity (up to 99percent diastereomeric purity).Possible mechanism for the highly effective assymmetric induction using "titanium template" is proposed.
