7637-97-0Relevant academic research and scientific papers
Studies on the Constituents of Chloranthus ssp. III. Six Sesquiterpenes from Chloranthus japonicus
Uchida, Masaaki,Koike, Yutaka,Kusano, Genjiro,Kondo, Yoshikazu,Nozoe, Shigeo,et al.
, p. 92 - 102 (2007/10/02)
Six sesquiterpene lactones (I-VI) were isolated and characterized as constituents of Chlorantus japonicus (Chloranthraceae).The lactones chloranthalactone A-E (I-V) were found to be lindenane derivatives, and lactone VI was identified as atractylenolide II.The structure of chloranthalactone C (III) was determined by X-ray chrystallographic analysis of a crystal of III in conjunction with the negative Cotton effect in the optical rotatory dispersion (ORD) curve and negative circular dichroism curve of the ketoalcohol (XII) prepared from III.The stereostructures of chlorantholactone A and B (I and II) were deduced from the ORD curves of the degradation products (VII and X).The cytotoxixities of these lactones against mouse lymphosarcoma L-5178Y cells were determined in comparison with that of helenalin, and they were found to show moderate cytotoxic effects.Keywords- Chloranthus japonicus; sesquiterpene lactones; lindendane derivatived; X-ray chrystallographic analysis; structural elucidation; cytotoxicity; mouse lymphosarcoma l-5178Y cells
