76371-96-5Relevant academic research and scientific papers
Alkylation of Enamines of Bis(ethylthio)acetaldehyde: Synthesis of Norpyrenophorin
Bates, Gordon S.,Ramaswamy, S.
, p. 904 - 906 (1980)
Alkylation of the potassium anion of the glyoxal derivatives (4) with halides and sulphonate esters, followed by acidic hydrolysis, provides good yields of the corresponding pyruvaldehyde α-thioacetals.
Enamines of 2,2-bis(ethylthio)ethanal: a convenient route to γ-keto crotonate derivatives
Bates, Gordon S.,Ramaswamy, S.
, p. 2466 - 2475 (2007/10/02)
A new α-oxoaldehyde reagent, 2,2-bis(ethylthio)ethanal 1, has been prepared in high yield from ethanedial.Alkylation of the potassium salt of the enamines of 1 with various alkylating agents followed by in situ hydrolysis of the intermediate imine afforded high yields of the alkylation products of 1.This new reagent was used in the synthesis of a chiral potential precursor of the macrocyclic fragment of cytochalasins A,B, and F, as well as in the syntheses of the physiologically active diolides pyrenophorin and norpyrenophorin.
