76384-36-6Relevant academic research and scientific papers
Catalytic asymmetric hydrogenation of quinoline carbocycles: Unusual chemoselectivity in the hydrogenation of quinolines
Kuwano, Ryoichi,Ikeda, Ryuhei,Hirasada, Kazuki
, p. 7558 - 7561 (2015)
The reduction of quinolines selectively took place on their carbocyclic rings to give 5,6,7,8-tetrahydroquinolines, when the hydrogenation was conducted in the presence of a Ru(η3-methallyl)2(cod)-PhTRAP catalyst. The chiral ruthenium catalyst converted 8-substituted quinolines into chiral 5,6,7,8-tetrahydroquinolines with up to 91:9 er. This journal is
Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
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, (2008/06/13)
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
Concise preparation of amino-5,6,7,8-tetrahydroquinolines and amino-5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of acetamidoquinolines and acetamidoisoquinolines
Skupinska, Krystyna A.,McEachern, Ernest J.,Skerlj, Renato T.,Bridger, Gary J.
, p. 7890 - 7893 (2007/10/03)
A method to prepare amino-substituted 5,6,7,8- tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The
Reaction of 2-Vinylpyridine and 2-(1-Methoxyvinyl)pyridine with Acrylic Acid Derivatives
Terent'ev, P. B.,Gulevich, Yu. V.,Gloriozov, I. P.,Kost, A. N.
, p. 1058 - 1060 (2007/10/02)
The regiospecificity of the reaction of 2-vinylpyridine and 2-(1-methoxyvinyl)pyridine with acrylonitrile and methyl acrylate was predicted on the basis of MO perturbation theory and was confirmed experimentally.The regioisomeric compositions of the reaction mixtures were studied by means of chromatographic mass spectrometry.
