76388-35-7Relevant academic research and scientific papers
A Convenient Synthesis of Substituted Piperazines via Aminomercuration-Demercuration of Diallylamines
Barluenga, J.,Najera, C.,Yus, M.
, p. 917 - 921 (2007/10/02)
cis- and trans-2,6-Bispiperazines (II) which bear equal or different substituents at each nitrogen are obtained in the reaction of N-substituted diallylamines with mercury(II) acetate and arylamines followed by a double decomposition process with potassium bromide.Their reduction with sodium borohydride lead to the corresponding 1,4-disubstituted cis- and trans-2,6-dimethylpiperazines III.Steric factors account for the remarkable stereoselectivity observed in the preparation of compounds IIIi-IIIn in which a 3:1 cis to trans ratio is found.
