7639-74-9Relevant academic research and scientific papers
Synthesis of substituted aryl enol ethers
Chang, Meng-Yang,Tai, Hang-Yi,Tsai, Chung-Yu,Chuang, Yi-Jing,Lin, Ying-Ting
, p. 6482 - 6485 (2014)
A facile route toward substituted aryl diarylvinyl ethers 4 is developed from CuI-mediated cross-coupling reaction of substituted phenols 2 with diarylvinyl bromides 3 in the presence of various bidentate-based ligands in DMF. Skeleton 3 is prepared by Yan's bromomethylenation of diarylketones 1 with CHBr3-TiCl4-Mg in the co-solvent of DME and CH2Cl2. The synthetic route obtains moderate yields from the one-step operation and the key structure of 4k is confirmed by X-ray crystallographic analysis. The CADD docking experiments of 4k have been included.
