76390-67-5Relevant academic research and scientific papers
Competitive formation of 4-aminoisoxazoles and 5-aminooxazoles in the cyclization reactions of O-alkylated hydroxyimino nitriles
Kislyi,Danilova,Semenov,Yakovenko,Dolgushin
, p. 1840 - 1847 (2006)
Base-catalyzed cyclization of O-alkylated α-hydroxyimino nitriles gave mixtures of 4-aminoisoxazoles and 5-aminooxazoles, their ratio depending on the substituent structures and the reaction conditions. The formation mechanism of 5-aminooxazoles in this reaction is discussed.
Synthesis of isoxazolo[4,5-e][1,4]diazepin-5-ones from 5-acyl-4- (haloacetylamino)isoxazoles
Kislyi, Victor P.,Danilova, Evgenia B.,Semenov, Victor V.
scheme or table, p. 85 - 86 (2012/07/30)
Treatment of 5-benzoyl-4-(iodoacetylamino)isoxazoles with alcoholic ammonia leads to isoxazolo[4,5-e][1,4]diazepin-5-ones, whereas the analogous chloroacetylamino derivatives are converted into a mixture of the deacylated 4-aminoisoxazoles and isoxazolo- [4,5-d]pyrimidines.
4-Aminoisoxazoles by Thorpe Cyclization
Gewald, Karl,Bellmann, Peter,Jaensch, Hans-Joachim
, p. 1623 - 1629 (2007/10/02)
Cyclization of α-(acylmethoxyimino)nitriles 1 in the presence of lithium hydroxide yields 5-acyl-4-aminoisoxazoles 2.Compounds 2f and 2a can be converted into the isoxazolopyrimidone 3 and the isoxazolopyridine 4.
