76391-43-0Relevant academic research and scientific papers
PROCESS FOR PREPARING BIOLOGICALLY ACTIVE DERIVATIVES OF 1,2,4-TRIAZOL AND INTERMEDIARIES USEFUL IN THIS PROCESS
-
, (2008/06/13)
A process for the preparation of fluconazole, which is a well blown antifungal agent, and of pharmaceutically acceptable salts thereof is disclosed, wherein a novel compound of the formula (IV) wherein R represents H, benzyl, triphenylmethyl and COOR1with R1being alkyl or aryl, preferably tert-butyl or ethyl, and Z represents a triazole radical or hydrazine radical optionally substituted by R being defined as above, optionally in the salt form, is reacted with s-triazine. The novel compound (IV) is an object of the invention as well.
Mesylhydroxylamines, III. The Reaction of Methane Sulfonyl Fluoride and Hydroxyamine
Brink, Klaus,Bliefert, Claus
, p. 1059 - 1062 (2007/10/02)
In the reaction of CH3SO2F with hydroxylamine the products CH3SO2N(H)OH, H3NOH(+)CH3SO3(-), and H5N2(+)CH3SO3(-) are formed.H2NO-Si(CH3)3 reacts with CH3SO2F to yield mainly H5N2(+)CH3SO3(-).These results are explained by consecutive reactions of the intermediate CH3SO2NH2. - Key words: Sulfonic Acid Fluorides, Hydroxylamines
