763910-07-2 Usage
Uses
Used in Pharmaceutical Industry:
6-(Piperazin-1-yl)-1H-indazole is used as a pharmacological agent for its potential therapeutic interventions in diseases such as cancer and viral infections. Its ability to inhibit the phosphatidylinositol-4-kinase IIIβ (PI4KB) enzyme makes it a promising candidate for targeting cellular processes involved in these diseases.
Used in Drug Development:
6-(Piperazin-1-yl)-1H-indazole is used as a lead compound in drug development due to its anti-proliferative and anti-inflammatory effects. These properties make it a valuable molecule for the creation of new drugs that can potentially treat a variety of conditions, including cancer and inflammatory disorders.
Used in Cancer Research:
6-(Piperazin-1-yl)-1H-indazole is used as a research tool in cancer research to study the role of phosphatidylinositol-4-kinase IIIβ (PI4KB) in the regulation of cellular processes related to tumor growth and progression. Understanding the mechanisms of action of 6-(Piperazin-1-yl)-1H-indazole can help in the development of targeted therapies for cancer treatment.
Used in Viral Infection Research:
6-(Piperazin-1-yl)-1H-indazole is used as a research compound in the study of viral infections, particularly in understanding the role of phosphatidylinositol-4-kinase IIIβ (PI4KB) in viral replication and pathogenesis. This knowledge can contribute to the development of antiviral drugs and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 763910-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,3,9,1 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 763910-07:
(8*7)+(7*6)+(6*3)+(5*9)+(4*1)+(3*0)+(2*0)+(1*7)=172
172 % 10 = 2
So 763910-07-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N4/c1-2-10(15-5-3-12-4-6-15)7-11-9(1)8-13-14-11/h1-2,7-8,12H,3-6H2,(H,13,14)
763910-07-2Relevant academic research and scientific papers
5-piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists
Liu, Kevin G.,Robichaud, Albert J.,Bernotas, Ronald C.,Yan, Yinfa,Lo, Jennifer R.,Zhang, Mei-Yi,Hughes, Zoe A.,Huselton, Christine,Zhang, Guo Ming,Zhang, Jean Y.,Kowal, Dianne M.,Smith, Deborah L.,Schechter, Lee E.,Comery, Thomas A.
scheme or table, p. 7639 - 7646 (2011/02/21)
As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for cognitive enhancement. Herein we report the identification of a novel series of 5-piperazinyl-3-sulfonylindazoles as potent and selective 5-HT6 antagonists. The synthesis, SAR, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.
6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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Page/Page column 34; 35-36, (2008/12/08)
The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1—R4 A, B, D, E, and G are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
AKT PROTEIN KINASE INHIBITORS
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Page/Page column 78-79; 76-77, (2008/06/13)
The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
