76400-53-8

Basic information

• Product Name: p-chlorobenzylidene-5-hydroxy-4-dihydro-2,5-thiophenecarboxylate-3 de methyle-(Z)
• Synonyms: p-chlorobenzylidene-5-hydroxy-4-dihydro-2,5-thiophenecarboxylate-3 de methyle-(Z)
• CAS NO: 76400-53-8
• Molecular Weight: 282.748
• Mol File: 76400-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: p-chlorobenzylidene-5-hydroxy-4-dihydro-2,5-thiophenecarboxylate-3 de methyle-(Z)(CAS DataBase Reference)
• NIST Chemistry Reference: p-chlorobenzylidene-5-hydroxy-4-dihydro-2,5-thiophenecarboxylate-3 de methyle-(Z)(76400-53-8)
• EPA Substance Registry System: p-chlorobenzylidene-5-hydroxy-4-dihydro-2,5-thiophenecarboxylate-3 de methyle-(Z)(76400-53-8)

Safety Data

• Hazardous Substances Data: 76400-53-8(Hazardous Substances Data)

Upstream product

• 2689-68-1 methyl 4-oxotetrahydrothiophene-3-carboxylate 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 76400-56-1 5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-4-methoxy-2,5-dihydro-thiophene-3-carboxylic acid (4-chloro-phenyl)-amide 
• 76418-59-2 chloro-4'-chlorobenzyl-5-hydroxy-4-thiophenecarboxanilide-3 
• 76400-66-3 p-chlorobenzyl-5-hydroxy-4-thiophenecarboxylate-3 de methyle 

Relevant articles and documents

(Z)-5-Benzylidene-2,5-dihydro-4-hydroxy-3-thiophenecarboxanilides: Synthesis and Isomerization into 5-Benzyl-4-hydroxy-3-thiophenecarboxanilides

Upon treatment with an arylamine in boiling xylene, the esters I yield predominantly the corresponding anilides II, along with a small but variable amount of the isomeric thiophene derivatives III (Table I).On the other hand, the derivatives III can be readily prepared by base- or acid-catalyzed isomerization of II.Esters I can also be isomerized to the corresponding thiophene derivatives IV (Scheme 6), but only in the presence of a strong acid (Table 4).The two series of isomers reported in Tables 2 and 3 present spectral differences which allow unambiguous structural assignments.The (Z)-configuration for compounds of Table 2 is confirmed by a NOE study carried out on the O-methyl derivatives 6a and 7a.