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Derivatives of 2-Sulfonamido-4,5-dimethoxyphenylacetic Acid and of 2-Carboxamido(2-chloroethyl)methylbenzenesulfonamides
Catsoulacos, P.,Camoutsis, Ch.
, p. 980 (2007/10/02)
Series of variously substituted amides of 2-sulfonamido-4,5-dimethoxyphenylacetic acid have been prepared.The reaction of diethylamine, piperidine, morpholine and bis(2-chloroethyl)amine with carbomethoxymethyl-3,4-dimethoxybenzenesulfonyl chloride produced the corresponding sulfonamido derivatives.Acid hydrolysis of the latter and action of thionyl chloride gave the chlorocarboxymethylbenzenesulfonamides.The acid chlorides of the sulfonamides were transformed to the 2-carboxamido-bis(2-chloroethyl)methylbenzenesulfonamides with bis(2-chloroethyl)amine.These agents were tested in L-1210 and P-388 leukemias and were found not to possess antitumor activity in these two transplantable tumor lines.
