764602-59-7Relevant academic research and scientific papers
Novel and green protocol for the synthesis of 2-iminohydantoins
Kumar, Vinod,Rana, Hemlata,Kaushik, M. P.
, p. 6423 - 6425,3 (2012/12/12)
A novel and green protocol for the synthesis of N-1 and C-5 substituted 2-iminohydantoins has been developed. Methyl N-cyano-N-alkyl/aryl-aminoacetate reacts with aqueous ammonia at room temperature in 10-30 min. The developed protocol does not require any work-up for the isolation or purification of the products; simple filtration can lead to the pure products in good to excellent yields.
