76462-82-3

Basic information

• Product Name: Uridine,5'-deoxy-5-fluoro-, 2',3'-diacetate
• Synonyms: 2',3'-Di-O-acetyl-5'-deoxy-5-fluorouridine
• CAS NO: 76462-82-3
• Molecular Formula: C13H15 F N2 O7
• Molecular Weight: 330.27
• Mol File: 76462-82-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.45g/cm³
• CAS DataBase Reference: Uridine,5'-deoxy-5-fluoro-, 2',3'-diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine,5'-deoxy-5-fluoro-, 2',3'-diacetate(76462-82-3)
• EPA Substance Registry System: Uridine,5'-deoxy-5-fluoro-, 2',3'-diacetate(76462-82-3)

Safety Data

• Hazardous Substances Data: 76462-82-3(Hazardous Substances Data)

Usage

General Description

Uridine,5'-deoxy-5-fluoro-, 2',3'-diacetate is a modified nucleoside derivative of uridine, a component of RNA. It is a synthetic chemical compound that has been studied for its potential use in treating certain neurological disorders, such as Alzheimer's disease and Parkinson's disease. Uridine,5'-deoxy-5-fluoro-, 2',3'-diacetate has been shown to have neuroprotective and cognitive-enhancing effects in animal studies, making it a promising candidate for further development as a therapeutic agent. Uridine,5'-deoxy-5-fluoro-, 2',3'-diacetate is also being investigated for its potential use as a precursor for the synthesis of fluorouridine, a nucleoside analog that has shown anti-cancer and antiviral properties. Overall, this compound has shown potential in a range of medical applications and continues to be researched for its therapeutic properties.

Upstream product

• 37076-71-4 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose 
• 51-21-8 5-fluoropyrimidine-2,4-diol 
• 78341-98-7 Methyl-(5-desoxy-2,3-di-O-acetyl-D-ribofuranosid) 
• 17242-85-2 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine 
• 4152-79-8 1,2-O-isopropylidene-5-methyl-5-deoxy-α-D-xylofuranose 
• 50600-39-0 5-deoxy-5-iodo-1,2-O-isopropylidene-alpha-D-xylofuranose 
• 108-24-7 acetic anhydride 
• 69260-71-5 doxifluridine 
• 51-21-8 5-fluorouracil 
• 27821-07-4 1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose 
• 78341-96-5 (3aS,4S,6aR)-4-(bromomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole 
• 84258-15-1 5-deoxy-5-iodo-1,2-O-isopropylidene-α-D-ribofuranose 
• 78341-97-6 1-O-methyl-2,3-O-isopropylidene-5-deoxy-D-ribofuranose 
• 13039-71-9 5-deoxy-1-methoxy-D-ribofuranoside 

Downstream Products

• 69260-71-5 doxifluridine 

Relevant articles and documents

Uracil nucleoside derivative and method for preparing deoxyuridine drug by using same (by machine translation)

The invention discloses (I) deoxy - D D-furan ribose 5 - styryl 1 - [2 - (1 - benzoate) derivative represented by the formula] and a preparation method, of the derivative, wherein the structure of the general formula (I) is shown. And the preparation method (I) of, deoxy - D D-furan ribose 5 - styryl 1 - [2 - (1 - benzoate) derivatives as above reaction raw materials can be used as a glycosyl donor to activate] under the conditions of the catalytic amount of the Lewis acid trifluoromethanesulfonate and N - iodosuccinimide, and, reaction efficient, yield 98%. reaching, is avoided in the conventional reaction system using an equivalent or excess of a Lewis acid, benzoyldiimide as a glycosyl donor. (by machine translation)

Rapid continuous synthesis of 5′-deoxyribonucleosides in flow via Br?nsted acid catalyzed glycosylation

A general, green, and efficient Br?nsted acid-catalyzed glycosylation serves as a key step in the one-flow, multistep syntheses of several important 5′-deoxyribonucleoside pharmaceuticals.

Stereospecific synthesis of the anticancer agent 5'-deoxy-5-fluorouridine and its 5'-deuteriated derivatives

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