764650-91-1Relevant articles and documents
Harnessing the Power of the Asymmetric Grignard Synthesis of Tertiary Alcohols: Ligand Development and Improved Scope Exemplified by One-Step Gossonorol Synthesis
Gilheany, Declan G.,Kavanagh, Saranna E.
supporting information, p. 8198 - 8203 (2020/11/18)
A series of N-substituted cyclohexyldiaminophenolic ligands for the asymmetric Grignard synthesis of tertiary alcohols is reported. The 2,5-dimethylpyrrole-decorated ligand led to improved enantioselectivities and broadened the scope of the methodology. As an exemplar, we report an unprecedented highly selective one-step synthesis of gossonorol in 93% ee, also constituting the shortest formal syntheses of natural products boivinianin B and yingzhaosu C.
Organocatalytic asymmetric transfer hydrogenation of nitroolefins
Martin, Nolwenn J. A.,Ozores, Lidia,List, Benjamin
, p. 8976 - 8977 (2008/02/10)
We describe a highly efficient and highly enantioselective Hantzsch ester mediated conjugate transfer hydrogenation of β,β-disubstituted nitroolefins that is catalyzed by a Jacobsen-type thiourea catalyst. Copyright
Highly enantioselective catalytic acyl-Pictet-Spengler reactions
Taylor, Mark S.,Jacobsen, Eric N.
, p. 10558 - 10559 (2007/10/03)
The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengle
