764661-24-7 Usage
Chemical Properties
4-(METHYL-D3-NITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE is Beige Solid
Uses
Different sources of media describe the Uses of 764661-24-7 differently. You can refer to the following data:
1. 4-(METHYL-D3-NITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE was present in the highest concentrations in smokeless tobacco out of the nitrosamines identified. Readily produces cancer in rats and hamsters
2. Labelled NNK (M325750). This compound was present in the highest concentrations in smokeless tobacco out of the nitrosamines identified. It is likely to be important in the etiology of cancers of the lung, oral cavity, and pancreas in people who use tabacco products. Readily produces cancer in rats and hamsters. Carcinogen.
Check Digit Verification of cas no
The CAS Registry Mumber 764661-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,4,6,6 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 764661-24:
(8*7)+(7*6)+(6*4)+(5*6)+(4*6)+(3*1)+(2*2)+(1*4)=187
187 % 10 = 7
So 764661-24-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3/i2D,4D,6D,8D
764661-24-7Relevant articles and documents
Syntheses of isotope-labeled tobacco-specific nitrosamines and their metabolites
Desai, Dhimant,Krzeminski, Jacek,El-Bayoumy, Karam,Amin, Shantu
, p. 226 - 230 (2008/12/20)
We report here on the syntheses of three deuterium-labeled tobacco-specific nitrosamines namely [2,4,5,6-d4]nitroso-nornicotine([2,4,5,6-d 4]NNN), 4-(methylnitrosamino)-1-(3-[2,4,5,6-d4]pyridyl)-1- butanone ([2,4,5,6-d4]NNK), and 4-(methyl-nitrosamino)-1-(3-[2,4,5,6- d4]pyridyl)-1-butanol ([2,4,5,6-d4]NNAL). A metabolite of NNK and myosmine, 4-hydroxy-1-(3-[2,4,5,6-d4]pyridyl)-1-butanone, was also synthesized. The synthetic strategy reported here is similar to that reported in the literature for the preparation of corresponding unlabeled compounds. The commercially available [2,4,5,6-d4]ethylnicotinate was used as starting material. During the course of these syntheses [2,4,5,6-d 4]myosmme and [2,4,5,6-d4]nornicotine were obtained as stable intermediates. These isotope-labeled compounds are useful internal standards for quantification of TSNA and their metabolites in smokers in molecular epidemiological studies. Copyright
