76470-45-6

Basic information

• Product Name: 1,3-Dioxolo[4,5-b]pyridine-6-carboxaldehyde (9CI)
• Synonyms: 1,3-Dioxolo[4,5-b]pyridine-6-carboxaldehyde (9CI);[1,3]dioxolo[4,5-b]pyridine-6-carbaldehyde
• CAS NO: 76470-45-6
• Molecular Formula: C7H5NO3
• Molecular Weight: 151.1195
• Product Categories: ALDEHYDE
• Mol File: 76470-45-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dioxolo[4,5-b]pyridine-6-carboxaldehyde (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolo[4,5-b]pyridine-6-carboxaldehyde (9CI)(76470-45-6)
• EPA Substance Registry System: 1,3-Dioxolo[4,5-b]pyridine-6-carboxaldehyde (9CI)(76470-45-6)

Safety Data

• Hazardous Substances Data: 76470-45-6(Hazardous Substances Data)

Usage

Chemical structure

Contains a pyridine ring and an aldehyde functional group

Classification

Organic compound

Industry use

Pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals

Application

Used as a reagent in organic synthesis, particularly in the formation of heterocyclic compounds

Potential applications

Medicinal chemistry and drug development

Safety precautions

Handle with care due to potential toxic or irritating effects if not used properly

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 34206-49-0 5-bromo-2,3-dihydroxy-pyridine 
• 74-97-5 chlorobromomethane 

Relevant articles and documents

PYRAZOLOPYRIDINE COMPOUND AS RET INHIBITOR AND APPLICATION THEREOF

Disclosed is a series of pyrazolopyridine compounds, and application thereof in the preparation of RET kinase inhibitors for treatment. Specifically disclosed is the compound represented by formula (I), or a pharmaceutically acceptable salt thereof.

Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.

A number of novel guanine derivatives containing heterocyclic moieties at the O6-position have been synthesized using a purine quaternary salt which reacts with alkoxides under mild conditions. Initially O6-substituents were investigated in which the benzene ring of the known agent, O6-benzylguanine, was replaced by unsubstituted heterocyclic rings. The ability of these agents to inactivate the DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase), both as pure recombinant protein and in the human lymphoblastoid cell line Raji, has been compared with that of O6-benzylguanine. The present paper focuses on O6-substituents with basic rings, and under standard conditions several of them proved more effective than benzyl for inactivation of both recombinant and Raji ATase. Among the pyridine derivatives, the 2-picolyl compound 7 is not very active in contrast to the 3- and 4-picolyl compounds, and this influenced our choice of isomers of other basic ring systems for study. Since halogen substitution in the thiophene ring considerably increased the activity (17 versus 6), similar modifications in the pyridine series were examined. The more polar O6-substituents in this study are on the whole compatible with the stereochemical requirements of the ATase protein, and their pharmacological properties may be valuable in subsequent in vivo investigations, particularly the thenyl (6), 5-thiazolylmethyl (12), 5-bromothenyl (17), and 2-chloro-4-picolyl (21) derivatives.