76499-12-2

Basic information

• Product Name: -L-phenylalanine
• Synonyms: -L-phenylalanine
• CAS NO: 76499-12-2
• Molecular Weight: 352.455
• Mol File: 76499-12-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: -L-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: -L-phenylalanine(76499-12-2)
• EPA Substance Registry System: -L-phenylalanine(76499-12-2)

Safety Data

• Hazardous Substances Data: 76499-12-2(Hazardous Substances Data)

Upstream product

• 2481-09-6 S-tert-Butyl-N-acetyl-L-cysteine hydrochloride 
• 65798-30-3 N-Formyl-S-tert-butyl-L-cysteine 
• 76499-08-6 (N-Formyl-S-tert-butyl-L-cysteinyl)-L-phenylalanine Methyl Ester 

Downstream Products

• 76499-15-5 N,N-Bis(formyl-L-cystinyl)-di-L-phenylalanine 
• 76499-13-3 -L-cysteinyl>-L-phenylalanine 

Relevant articles and documents

tert-Butyl group as thiol protection in peptide synthesis

S-tert-Butylcysteine was obtained by a new method. A number of its N-protected derivatives and esters were synthesized. Syntheses of several peptides containing tert-butyl and acetamidomethyl or benzyl thioethers of cysteine were carried out. The tert-butyl group was removed from the thiol group of peptides by treatment with (2-nitrophenyl)sulfenyl chloride (NpsCl). The S-(2-nitrophenyl)sulfenyl derivatives so obtained were converted either into cysteine by reduction or into cystine derivatives by disproportionation. Owing to the mild deprotection conditions and the great stability of the S-tert-butyl group, the other protecting groups, particularly those of the thiols, could be easily removed from a variety of combinations.