765-55-9

Usage

Uses

Used in Pharmaceutical Industry:
Thietane-3-carboxylic acid is used as a building block for the synthesis of various pharmaceuticals due to its unique structural properties and biological activity, contributing to the development of novel drug candidates.
Used in Agrochemical Industry:
Thietane-3-carboxylic acid is utilized as a key component in the synthesis of agrochemicals, leveraging its chemical properties to create effective compounds for agricultural applications.
Used in Neurological Disorder Treatment:
Thietane-3-carboxylic acid is employed as a potential anticonvulsant agent for the treatment of neurological disorders, given its demonstrated therapeutic effects and potential to modulate relevant biological pathways.
Used in Drug Discovery Research:
In the field of drug discovery, thietane-3-carboxylic acid serves as an important molecule for research, providing insights into the development of new therapeutic agents and enhancing understanding of its role in medicinal chemistry.

Upstream product

• 1337882-54-8 thietane-3-carbonitrile 

Relevant academic research and scientific papers

TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS

The present invention provides tetrahydropyridopyrimidines and tetrahydropyridopyridines having the general formula (I) wherein R1, R2, U, W, X, Y and Z are as described herein, as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment and prophylaxis of hepatitis B virus infections.

PROCESSES FOR THE PREPARATION OF THIETANAMINE

The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a compound of formula (II) with a nucleophile in the presence of water to give a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N3-, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NH2OH and NH3; and b. when the nucleophile used in step a. is N3- or NH2OH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S-N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C-N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I).