765-77-5Relevant academic research and scientific papers
Peptidylarginine deiminase inhibitor and application thereof
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Paragraph 0520; 0522; 0523; 0524, (2019/09/10)
The invention belongs to the technical field of medicine, and particularly relates to a peptidylarginine deiminase PAD4 inhibitor compound shown in a formula (I) or pharmaceutically acceptable salts,stereoisomers and tautomers thereof, as well as pharmaceutical compositions, pharmaceutical preparations and application thereof. X, Y, R1, R2, R3, R4, R5, R7, R8, R9, ring B and m are as defined in the specification. The compound has inhibitory effect on peptidylarginine deiminase PAD4, and can be used for treating various diseases, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, multiple sclerosis, cystic fibrosis, cancer, cutaneous lupus erythematosus, asthma and psoriasis.
HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND
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Paragraph 0585, (2015/11/24)
A novel α-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R1 is the same or different, and represents a halogen atom, or a C1-C3 alkyl group; R2 represents a hydrogen atom, or a C1-C6 alkyl group; p represents an integer of 0 to 5; V represents CR3 wherein R3 represents a hydrogen atom, an amino group, a nitro group, or a C1-C3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.
4-?(thien-3-yl)methyl!-imidazole analgesics
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, (2008/06/13)
Described herein are 4-?(thien-3-yl)methyl!-imidazoles of the formula: STR1 wherein R is hydrogen or methyl, and X is C1-4 alkyl, bromine or chlorine; or STR2 wherein Y is hydrogen, C1-4 alkyl, bromine or chlorine, and Z is C1-4
Diazirine derivatives of aromatic heterocyclic compounds
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, (2008/06/13)
Compounds of the formula STR1 in which Het represents an optionally substituted aromatic heterocycle having a sulphur or oxygen hetero atom and attached via a ring carbon atom, and X is halogen, alkyl, alkaryl, cyano, alkoxy, mono- or di-alkylamino, acylo
Generation and Trapping of (Thiophen-3-yl)halogenocarbenes from 3-Dihalomethylthiophenes or 3-Chloro-3-(thiophen-3-yl)diazirine
Baird, Mark S.,Bruce, Ian
, p. 2872 - 2893 (2007/10/02)
Reaction of 3-dihalogenomethylthiophenes with potassium t-butoxide at 0 deg C generates (thiophen-3-yl)halogenocarbenes, or related carbenoids, which are trapped by simple alkenes to give 1-(thiophen-3-yl)-1-halogenocyclopropanes in moderate to good yield
