7651-40-3Relevant articles and documents
Chiral barbituric acid compound and preparation method thereof
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Paragraph 0024; 0027; 0030-0031, (2021/02/06)
The invention discloses a chiral barbituric acid compound and a preparation method thereof. The chiral barbituric acid compound is an optically active compound having a structure represented by the following formula (1), and comprises a levorotatory body or a dextrorotatory body having the same chemical general formula: in the formula: * represents a chiral carbon atom, substituent groups R1 and R3 are respectively and independently selected from alkyl, the substituent R2 is selected from alkyl or allyl, and X is selected from O or S. Racemic propargyl carbonate and malonate compounds are usedas initial raw materials, bis-(1, 5-cyclooctadiene) nickel metal is used as a catalyst, a chiral phosphine reagent is used as a ligand, Lewis acid is used as a co-catalyst, and asymmetric propargyl reaction and subsequent reduction and condensation reaction are performed under the assistance of alkali, the chiral barbituric acid compound is prepared with high yield, high enantioselectivity and approximate gram scale in an accurate and rapid mode for the first time, and the method has biomedical practicability and industrial application prospects.
