Propargyl Methanethiosulfonate (also known as PMTS) is a chemical reagent that is characterized as a faint yellow oil. It is known for its specific and rapid reaction with thiols, leading to the formation of mixed disulfides. This property makes PMTS a valuable tool in the field of biochemistry and molecular biology for studying the structures and functions of various proteins and receptors.
7651-65-2
Post Buying Request-
-
Basic information
- Product Name: Propargyl Methanethiosulfonate
- Synonyms: 2-Propyne-1-thiol Methanesulfonate;Propargyl Methanethiosulfonate;Thiomethanesulfonic Acid S-2-Propynyl Ester
- CAS NO:7651-65-2
- Molecular Formula: C4H6O2S2
- Molecular Weight: 150.22
- EINECS: N/A
- Product Categories: MTS and Sulfhydryl Active Reagents;MTS & Sulfhydryl Active Reagents
- Mol File: 7651-65-2.mol
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
- Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
- Stability: Moisture and Light Sensitive
- CAS DataBase Reference: Propargyl Methanethiosulfonate(CAS DataBase Reference)
- NIST Chemistry Reference: Propargyl Methanethiosulfonate(7651-65-2)
- EPA Substance Registry System: Propargyl Methanethiosulfonate(7651-65-2)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 7651-65-2(Hazardous Substances Data)
7651-65-2 Suppliers
Recommended suppliers
7651-65-2 Usage
Uses
1. Used in Biochemical Research:Propargyl Methanethiosulfonate is used as a chemical probe for investigating the structures of different receptor channels, such as the ACh receptor channel, the GABA receptor channel, and lactose permease. Its ability to form mixed disulfides with thiols allows researchers to explore the conformational changes and interactions of these receptors in a controlled manner.
2. Used in Mapping Pore-Lining Regions:
Propargyl Methanethiosulfonate is employed as a mapping agent for identifying and characterizing the pore-lining regions of the ryanodine receptor. By reacting with thiols present in these regions, PMTS helps researchers understand the structural and functional aspects of the ryanodine receptor, which plays a crucial role in calcium release and cellular signaling.
3. Used in Pharmaceutical Industry:
In the pharmaceutical industry, Propargyl Methanethiosulfonate is utilized for its potential applications in drug discovery and development. Its ability to modify thiols in proteins and receptors can be harnessed to study the mechanisms of drug action, develop new therapeutic agents, and improve the understanding of protein-target interactions.
4. Used in Drug Delivery Systems:
Similar to gallotannin, PMTS can also be incorporated into drug delivery systems to enhance the bioavailability and therapeutic outcomes of certain drugs. Its reactivity with thiols can be exploited to design targeted drug delivery systems that specifically release their payload upon encountering the desired biological target.
Check Digit Verification of cas no
The CAS Registry Mumber 7651-65-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,5 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.Calculate Digit Verification of CAS Registry Number 7651-65:
(6*7)+(5*6)+(4*5)+(3*1)+(2*6)+(1*5)=112
112 % 10 = 2
So 7651-65-2 is a valid CAS Registry Number.
7651-65-2Upstream product
7651-65-2Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 7651-65-2
Propargyl Methanethiosulfonate
