76510-61-7

Basic information

• Product Name: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE
• Synonyms: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE;5-iodo-2-(Methylthio)pyriMidin-4-ol;5-iodo-2-(methylthio)-4(3H)-Pyrimidinone;2S-Methyl-5-iodo-2-thiouracil;5-iodo-2-methylsulfanyl-1H-pyrimidin-6-one;4(3H)-Pyrimidinone,5-iodo-2-(methylthio)-;5-Iodo-2-(Methylthio)-4(3H)-Pyrimidinone(WX638047)
• CAS NO: 76510-61-7
• Molecular Formula: C₅H₅IN₂OS
• Molecular Weight: 268.08
• Mol File: 76510-61-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE(76510-61-7)
• EPA Substance Registry System: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE(76510-61-7)

Safety Data

• Hazardous Substances Data: 76510-61-7(Hazardous Substances Data)

Upstream product

• 5751-20-2 2-methylthio-1H-pyrimidin-4-one 
• 6328-58-1 4-Hydroxy-6-methyl-2-methylthiopyrimidine 
• 5751-20-2 2-Methylthiouracil 
• 5751-20-2 2-(methylsulfanyl)pyrimidin-4-ol 

Downstream Products

• 864543-58-8 (4-chlorophenyl)-(4-chloro-2-methylsulfanylpyrimidin-5-yl)methanone 
• 864543-57-7 (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-(2-chlorophenyl)methanol 

Relevant articles and documents

A class of pyrazolopyrimidine diazepine derivatives with antitumor effect

The present invention relates to the field of medicine, wherein a pyrazolopyrimidine diazepine derivative represented by a formula I can significantly inhibit three targets such as Aurora A, Aurora Band vascular endothelial growth factor receptor 2 (VEGFR2/KDR), or two or one of the three targets, and the pharmacological experiment results show that the pyrazolopyrimidine diazepine derivative hassignificant antitumor activity, can be used to be developed into antitumor drugs for treatment or control of malignant tumors, especially drugs for treatment or control of gastric cancer, liver cancer, lung cancer, breast cancer, colon cancer and the like. The formula I is defined in the specification.

A New Synthesis of 2-Aminoindoles and 6-Aminopyrrolo[3,2- d ]pyrimidines from π-Deficient 1,2-Dihaloarenes and Geminal Enediamines

An efficient approach for the synthesis of fused 2-aminopyrroles via geminal enediamines and π-deficient 1,2-dihaloarenes is presented. The two-step methodology includes aromatic nucleophilic substitution of the activated halogen of dihaloarene with enediamine C-nucleophilic center followed by Cu-catalyzed intramolecular N-arylation. This approach allows access to a variety of 2-amino-6-nitroindoles and 6-aminopyrrolo[3,2-d]pyrimidines (including N-mono- and N,N-disubstituted) in moderate and good yields under mild conditions.

Microwave-assisted C-5 iodination of substituted pyrimidinones and pyrimidine nucleosides

Direct microwave-assisted iodination of several pyrimidinones and pyrimidine nucleosides with N-iodosuccinimide to give the corresponding 5-iodo derivatives is described. Application of this reaction to polymer-bound pyrimidinones was also investigated.