76510-64-0

Basic information

• Product Name: 5-Iodo-6-methyl-2-(methylthio)-1H-pyrimidin-4-one
• Synonyms: 5-Iodo-4-hydroxy-6-methyl-2-methylthiopyrimidine;5-Iodo-6-methyl-2-(methylthio)-1H-pyrimidin-4-one;5-Iodo-6-Methyl-2-(Methylsulfanyl)Pyrimidin-4-Ol;4(1H)-Pyrimidinone, 5-iodo-6-methyl-2-(methylthio)-;5-Iodo-6-Methyl-2-(Methylsulfanyl)Pyrimidin-4-Ol(WXC03168)
• CAS NO: 76510-64-0
• Molecular Formula: C₆H₇IN₂OS
• Molecular Weight: 282.10205
• Mol File: 76510-64-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 209-212°C (decomposition)
• Appearance: /
• CAS DataBase Reference: 5-Iodo-6-methyl-2-(methylthio)-1H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-6-methyl-2-(methylthio)-1H-pyrimidin-4-one(76510-64-0)
• EPA Substance Registry System: 5-Iodo-6-methyl-2-(methylthio)-1H-pyrimidin-4-one(76510-64-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 76510-64-0(Hazardous Substances Data)

Upstream product

• 56-04-2 2-mercapto-6-methylpyrimidin-4(3H)-one 
• 6328-58-1 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one 
• 6328-58-1 4-Hydroxy-6-methyl-2-methylthiopyrimidine 

Downstream Products

• 1208989-31-4 C₃₀H₃₃F₃N₆O₄S 

Relevant articles and documents

Substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

CONDENSED HETEROAROMATIC RING SYSTEMS. VII. SYNTHESIS OF THIENOPYRIDINES, THIENOPYRIMIDINES, AND FUROPYRIDINES FROM o-SUBSTITUTED N-HETEROARYLACETYLENES

The cross-coupling reaction of 2-chloro-3-iodo- and 4-chloro-3iodopyridines with phenylacetylene in the presence of dichlorobis(triphenylphosphine)palladium occured at the 3-position.The 3-ethynylpyridines containing an adjacent chloro group were converti