76513-52-5Relevant academic research and scientific papers
CEREBLON E3 LIGASE INHIBITORS
-
, (2021/03/05)
The present disclosure provides compounds represented by Formula I: wherein R2a, R2b, R2c, R2d, R3, R13, and Z are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are cereblon (CRBN) ubiquitination inhibitors or monofunctional synthetic intermediates that can be used to prepare PROTAC molecules. CRBN ubiquitination inhibitors and PROTAC molecules are useful for the treatment of cancer and other diseases.
A DIELS-ALDER ROUTE TO 7,8-DISUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINES
Finkelstein, Joseph A.,Perchonock, Carl D.
, p. 3323 - 3326 (2007/10/02)
A novel synthesis of some difficultly accessible tetrahydroisoquinolines has been developed, utilizing a Diels-Alder reaction sequence.
