76518-58-6Relevant academic research and scientific papers
THROMBIN INHIBITORS
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, (2008/06/13)
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and are selected from the group consisting of: or a pharmaceutically acceptable salt thereof, wherein T is selected from the group consisting of D, E, F, G, H, I, and J are independently N or CY 1, provided that the number of such variables D, E, F, G, H, I, and J representing N is 0, 1, or 2; K, L, M and Q are independently NH or CY1Y2, provided that the number of such variables D, E, F, K, L, M, and Q representing N is 0, 1, or 2; Y1 and Y2 are independently selected from the group consisting of hydrogen, C1-4 alkyl, halogen, anino, or hydroxy; A is
1-Phenyl isoquinoline-5-acetic acid compounds and analgesic compositions thereof
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, (2008/06/13)
Novel isoquinoline derivatives of the general formula STR1 wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula STR2 in which R2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group; R1 represents a hydrogen atom or a lower alkyl group; and Y represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group; or a salt thereof; a process for the production thereof. The above compound is useful as an anti-inflammatory and analgesic agent.
