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76527-75-8

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76527-75-8 Usage

Description

N-[(DIPHENYLPHOSPHINYL)METHYL]-N-METHYLANILINE, a phosphine oxide derivative with the molecular formula C20H19N, is a white to light yellow solid at room temperature. It is soluble in organic solvents such as dichloromethane and tetrahydrofuran. This chemical compound is utilized in organic synthesis as a ligand for transition metal catalysis, playing a crucial role in the formation of carbon-carbon and carbon-heteroatom bonds.

Uses

Used in Organic Synthesis:
N-[(DIPHENYLPHOSPHINYL)METHYL]-N-METHYLANILINE is used as a ligand in organic synthesis for transition metal catalysis, facilitating the formation of carbon-carbon and carbon-heteroatom bonds. Its unique properties make it a valuable component in various chemical reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-[(DIPHENYLPHOSPHINYL)METHYL]-N-METHYLANILINE is used as a building block for the synthesis of complex organic molecules. Its potential applications in this field are attributed to its ability to form stable complexes with transition metals, which can be utilized in the development of new drugs.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, N-[(DIPHENYLPHOSPHINYL)METHYL]-N-METHYLANILINE is employed as a precursor for the synthesis of complex organic molecules. Its role in creating stable metal complexes can contribute to the development of new agrochemicals with improved properties and efficacy.

Check Digit Verification of cas no

The CAS Registry Mumber 76527-75-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,5,2 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 76527-75:
(7*7)+(6*6)+(5*5)+(4*2)+(3*7)+(2*7)+(1*5)=158
158 % 10 = 8
So 76527-75-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H20NOP/c1-21(18-11-5-2-6-12-18)17-23(22,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,17H2,1H3

76527-75-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(diphenylphosphorylmethyl)-N-methylaniline

1.2 Other means of identification

Product number -
Other names N-methyl-N-anilinomethyl diphenylphosphine oxide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76527-75-8 SDS

76527-75-8Relevant articles and documents

Organic photoredox catalytic α-C(sp3)-H phosphorylation of saturated: Aza -heterocycles

Yi, Ming-Jun,Xiao, Teng-Fei,Li, Wen-Hui,Zhang, Yi-Fan,Yan, Pen-Ji,Zhang, Baoxin,Xu, Peng-Fei,Xu, Guo-Qiang

, p. 13158 - 13161 (2021/12/16)

A metal-free C(sp3)-H phosphorylation of saturated aza-heterocycles via the merger of organic photoredox and Br?nsted acid catalyses was established under mild conditions. This protocol provided straightforward and economic access to a variety of valuable α-phosphoryl cyclic amines by using commercially available diarylphosphine oxide reagents. In addition, the D-A fluorescent molecule DCQ was used for the first time as a photocatalyst and exhibited an excellent photoredox catalytic efficiency in this transformation. A series of mechanistic experiments and DFT calculations demonstrated that this transformation underwent a sequential visible light photoredox catalytic oxidation/nucleophilic addition process.

A New Access to 3-(2'-Aminovinyl)indoles and Their First Diels-Alder Reactions

Pindur, Ulf,Otto, Christian

, p. 403 - 406 (2007/10/02)

3-Acylindoles react with α-amino-α'-diphenylphosphinoyl-substituted carboanions to 3-(2'-aminovinyl)indoles (7 and 12) via carbinols.The electron-rich 3-vinylindoles 7 and 12 undergo Diels-Alder reactions with N-phenylmaleimide.

Synthesis of indoles using (N-arylaminomethyl)diphenylphosphine oxides

Zorgdrager, Jan,Broekhof, Nico L. J. M.,Gen, Arne van der

, p. 441 - 444 (2007/10/02)

A new route for the synthesis of 1,3-disubstituted indoles, based on (N-arylaminomethyl)-diphenylphosphine oxide (1) chemistry, is described.Adducts 2, obtained by addition of the carbanions from 1 to aldehydes, were treated with p-toluenesulfonic acid to form the desired indoles 4 in good yields, without isolation of the intermediate amino ketones 3.

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