76529-00-5Relevant academic research and scientific papers
CHIRALITY CONTROL BY KINETIC PROTONATION: ENANTIOSELECTIVE SYNTHESES OF (+)-VELBANAMINE, (-)-ISOVELBANAMINE, AND (+)-CLEAVAMINE
Takano, Seiichi,Uchida, Wataru,Hatakeyama, Susumi,Ogasawara, Kunio
, p. 733 - 736 (2007/10/02)
Optimal conditions for inversion of chirality at 2-position of the 2-alkyllactone(5) have been established.By utilizing the inversion method developed, three indole alkaloids, (+)-velbanamine(16), (-)-isovelbanamine(17), and (+)-cleavamine(18), have been synthesized from the chiral lactone(1) which has been previously used for the syntheses of the enantiomers of these alkaloids.
ENANTIOSELECTIVE SYNTHESIS OF (-)-VELBANAMINE AND (+)-ISOVELBANAMINE USING L-GLUTAMIC ACID AS CHIRAL TEMPLATE
Takano, Seiichi,Yonaga, Masahiro,Chiba, Kenji,Ogasawara, Kunio
, p. 3697 - 3700 (2007/10/02)
Enantioselective synthesis of (-)-velbanamine (1) and (+)-isovelbanamine (2) has been accomplished using L-glutamic acid as chiral template.
