765296-48-8

Upstream product

• 4079-52-1 methoxymethyl phenyl ketone 
• 20780-76-1 5-iodoisatin 
• 3789-59-1 (R)-1-phenylpropylamine 

Downstream Products

• 1033050-93-9 3-methoxy-6-[¹¹C]methyl-2-phenyl-N-[(S)-1-phenylpropyl]quinoline-4-carboxamide 
• 1033051-02-3 3-methoxy-6-methyl-2-phenyl-N[(S)-1-phenylpropyl]quinoline-4-cvarboxamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel fluoro and iodo quinoline carboxamides as potential ligands of NK-3 receptors for in vivo imaging studies

In order to develop radioligands of human NK-3 receptor (hNK-3r) for imaging studies by positron emission tomography (PET) or single photon emission computed tomography (SPECT), a new series of fluoro- and iodo-quinoline carboxamides were synthesized and evaluated in a target receptor binding assay. Compared to the unsubstituted parent compound SB 223 412 (Ki= 27nM±9), affinity was not altered for the analogues 1c and 2c bearing a fluorine in position 8 (Ki～24-27nM), and was only slightly reduced for compounds 1b, 2b, 1e and 2e fluorinated or iodinated at the position 7 (Ki～49-67nM). A drastic reduction in binding (K i>115nM) was observed for all other halogenated compounds 1a, 2a, 1d, 2d, 1f and 2f.