7653-41-0

Usage

Benzoyl group

Presence of a benzoyl group (C6H5CO-)
The compound contains a benzoyl group, which is a carbonyl group (C=O) bonded to a phenyl ring (C6H5-). This group is responsible for some of the compound's chemical properties and reactivity.

Methoxy substituent

Presence of a methoxy group (-OCH3)
A methoxy group is attached to the phenyl ring in the benzoyl moiety, which can influence the compound's reactivity, polarity, and solubility.

Use in organic synthesis

As a building block or reagent
2-(3-Methoxybenzoyl)hydrazinecarbothioamide may be used as a building block or reagent in organic synthesis, allowing chemists to create more complex molecules by reacting it with other compounds.

Potential applications

Dependent on chemical structure and context
The specific applications of 2-(3-Methoxybenzoyl)hydrazinecarbothioamide will depend on its chemical structure and the context in which it is being used. This could include pharmaceuticals, agrochemicals, or other industries requiring specialized chemical compounds.

Upstream product

• 5368-81-0 methyl 3-methoxybenzoate 
• 586-38-9 3-Methoxybenzoic acid 
• 5785-06-8 3-methoxybenzoic hydrazide 
• 1147550-11-5 ammonium thiocyanate 
• 1711-05-3 m-anisoyl chloride 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 1673-44-5 2-amino-5-(3'-methoxyphenyl)-1,3,4-oxadiazole 
• 419540-45-7 3-(3-methoxyphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione 

Relevant academic research and scientific papers

Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction

Defective in cullin neddylation 1(DCN1) is a co-E3 ligase that is important for cullin neddylation. Dysregulation of DCN1 highly correlates with the development of various cancers. Herein, from the initial high-throughput screening, a novel hit compound 5a containing a phenyltriazole thiol core (IC50 value of 0.95 μM for DCN1-UBC12 interaction) was discovered. Further structure-based optimization leads to the development of SK-464 (IC50 value of 26 nM). We found that SK-464 not only directly bound to DCN1 in vitro, but also engaged cellular DCN1, suppressed the neddylation of cullin3, and hindered the migration and invasion of two DCN1-overexpressed squamous carcinoma cell lines (KYSE70 and H2170). These findings indicate that SK-464 may be a novel lead compound targeting DCN1-UBC12 interaction.

Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence

The human pathogen Pseudomonas aeruginosa employs alkyl quinolones for cell-to-cell communication. The Pseudomonas quinolone signal (PQS) regulates various virulence factors via interaction with the transcriptional regulator PqsR. Therefore, we consider t

Synthesis of 5-(2-,3- and 4-methoxyphenyl)-4H-1,2,4-triazole-3-thiol derivatives exhibiting anti-inflammatory activity

New S-alkylated 5-(2-,3- and 4-methoxyphenyl)-4H-1,2,4-triazole-3-thiols (5a-c, 6a-c) and 5-(2-,3- and 4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3- thiols (7a-c, 8a-c, 9a-c) were synthesized by the alkylation of 3-(2-,3- and 4-methoxyphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones (3a-c) or 3-(2-,3- and 4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-1,2,4-triazole-5-thiones (4a-c) with 1-iodobutane or 1-(1,3-benzodioxol-5-yl)-2-bromo-1-ethanone, 2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-ethanone and 2-bromo-1-(3,4- dihydro-2H-1,5-benzodioxepin-7-yl)-1-ethanone. Compounds 3a-c and 4a-c were synthesized by the acylation of thiosemicarbazide or 4-phenyl-3- thiosemicarbazide with 2-, 3- and 4-methoxybenzoyl chlorides and further cyclization of the obtained acylderivatives 1a-c and 2a-c. The synthesized compounds 4a-c, 5a, 6a-c, 7a-c, 8a-c, 9b,c exhibit anti-inflammatory activity.