76530-44-4 Usage
Uses
Used in Pharmaceutical Industry:
Azamulin is used as a broad-spectrum antibiotic in the pleuromutilin class for its antimicrobial properties.
Used in Drug Metabolism Research:
Azamulin is used as a selective CYP3A4 inhibitor for pretreating primary hepatocyte cells and in prostate cancer cell lines LNCaP and MDAPCa2b, helping researchers understand the body's metabolism of drugs or xenobiotics.
Used in Drug Development:
Azamulin is used as a tool to study the role of specific cytochrome P450 mixed function oxidase sub-types in drug metabolism, which is important for the development of new drugs and understanding drug interactions.
Biochem/physiol Actions
Azamulin is a derivative of the antibiotic pleuromutilin. The compound is a very specific inhibitor of the CYP3A family (IC50 = 0.03-0.24 μM). Azamulin is 15 and 13 fold more active against CYP3A4 compared to CYP3A5 or CYP3A7, respectively, and is at least 100 fold selective over other CYP isoforms, with the exception of CYP2J2 (approximately 50-fold).
Check Digit Verification of cas no
The CAS Registry Mumber 76530-44-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,5,3 and 0 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 76530-44:
(7*7)+(6*6)+(5*5)+(4*3)+(3*0)+(2*4)+(1*4)=134
134 % 10 = 4
So 76530-44-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H38N4O4S/c1-6-22(4)11-16(32-17(30)12-33-21-26-20(25)27-28-21)23(5)13(2)7-9-24(14(3)19(22)31)10-8-15(29)18(23)24/h13-14,16,18-19,31H,6-12H2,1-5H3,(H3,25,26,27,28)/t13?,14-,16+,18-,19-,22+,23-,24-/m0/s1
