765300-56-9Relevant academic research and scientific papers
A new scalable synthesis of entecavir
Gioti, Efthymia G.,Koftis, Theocharis V.,Neokosmidis, Efstratios,Vastardi, Elli,Kotoulas, Stefanos S.,Trakossas, Sakellarios,Tsatsas, Theodoros,Anagnostaki, Elizabeth E.,Panagiotidis, Theodoros D.,Zacharis, Constantinos,Tolika, Evanthia P.,Varvogli, Anastasia-Aikaterini,Andreou, Thanos,Gallos, John K.
supporting information, p. 519 - 527 (2017/12/29)
A new synthesis of entecavir from D-glucose in an average total yield of 3.5% was achieved via an intramolecular nitrile oxide cycloaddition (INOC) reaction and a Peterson olefination as key-steps. The present process was designed for industrial application, using widely available raw materials, simple and cheap reagents and avoiding low reaction temperatures, which are very common in the synthetic approaches towards similarly complex structures.
Studies directed towards the total synthesis of feigrisolide B
Sharma,Kumar, K. Raman
, p. 2323 - 2326 (2007/10/03)
Attempts directed towards the total synthesis of feigrisolide B resulted in the synthesis of lactones 1 and 2. The synthesis of 1 and 2 was achieved from d-glucose and l-malic acid, respectively, with a Ti(IV) mediated diastereoselective aldol reaction as
