765305-18-8Relevant articles and documents
Angiogenesis inhibitor TX-1898: Syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers
Jin, Cheng-Zhe,Nagasawa, Hideko,Shimamura, Mariko,Uto, Yoshihiro,Inayama, Seiichi,Takeuchi, Yoshio,Kirk, Kenneth L.,Hori, Hitoshi
, p. 4917 - 4927 (2004)
(R)- and (S)-Epichlorohydrins were used to prepare the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazoles that function as hypoxic cell radiosensitizers. The synthetic design allowed for introduction of a side chain of varying bulk th