765311-76-0

Upstream product

• 765311-70-4 (2S,5R)-1-O-benzoyl-5,6-di(tert-butyldimethylsilyloxy)-3E-fluoro-2-hydroxy-2-ethynyl-3-hexene 
• 765311-67-9 (5R)-1-O-benzoyl-2-hydroxy-5,6-di(tert-butyldimethylsilyloxy)-3E-fluoro-3-hexene 
• 765311-68-0 Benzoic acid (E)-(S)-5,6-bis-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-2-oxo-hex-3-enyl ester 
• 765311-72-6 (2S,5R)-1-O-benzoyl-5,6-dihydroxy-3E-fluoro-2-hydroxy-2-ethynyl-3-hexene 
• 765311-74-8 Benzoic acid (E)-(S)-2-ethynyl-3-fluoro-2-hydroxy-5-oxo-pent-3-enyl ester 
• 108-24-7 acetic anhydride 

Downstream Products

• 765311-86-2 1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine 
• 765311-90-8 9-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)-N⁶-isobutyryladenine 
• 765311-87-3 1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)-N⁴-benzoylcytosine 

Relevant academic research and scientific papers

Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.

An efficient procedure has been developed for the synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl D- and L-furanosyl nucleosides (1 and 2) starting from 2,3-O-isopropylidene-d-glyceraldehyde. The key intermediate 1-O-benzoyl-3E-fluoro-3,4-