765314-20-3Relevant articles and documents
Novel tetrahydro-thieno pyridyl oxazolidinone: An antibacterial agent
Lohray, Braj Bhushan,Lohray, Vidya Bhushan,Srivastava, Brijesh Kumar,Kapadnis, Prashant B.,Pandya, Purvi
, p. 4557 - 4564 (2007/10/03)
We have synthesized and evaluated antibacterial activity of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones against several Gram-positive pathogens. Effect of various substituents on 5-position of the oxazolidinone ring has been studied. Synthesis of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones have been reported. They have been screened against a panel of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. A SAR has been developed. Compound 15 showed comparable activity (MIC) to linezolid and superior to eperezolid.