76551-40-1

Basic information

• Product Name: N~6~-(4-fluorobenzyl)-N~6~-methylpteridine-2,4,6-triamine
• Synonyms: 2,4,6-pteridinetriamine, N~6~-[(4-fluorophenyl)methyl]-N~6~-methyl-
• CAS NO: 76551-40-1
• Molecular Formula: C₁₄H₁₄FN₇
• Molecular Weight: 299.3063
• Mol File: 76551-40-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 599.9°C at 760 mmHg
• Flash Point: 316.6°C
• Density: 1.467g/cm³
• Vapor Pressure: 2.38E-14mmHg at 25°C
• Refractive Index: 1.757
• CAS DataBase Reference: N~6~-(4-fluorobenzyl)-N~6~-methylpteridine-2,4,6-triamine(CAS DataBase Reference)
• NIST Chemistry Reference: N~6~-(4-fluorobenzyl)-N~6~-methylpteridine-2,4,6-triamine(76551-40-1)
• EPA Substance Registry System: N~6~-(4-fluorobenzyl)-N~6~-methylpteridine-2,4,6-triamine(76551-40-1)

Safety Data

• Hazardous Substances Data: 76551-40-1(Hazardous Substances Data)

Upstream product

• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 17714-06-6 6-chloro-2,4-pteridinediamine 
• 405-66-3 (4-Fluoro-benzyl)-methyl-amine 

Relevant articles and documents

Folate Antagonists. 18. Synthesis and Antimalarial Effects of N6-(Arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and Related N6,N6-Disubstituted 2,4,6-Pteridinetriamines

N6-(Arylmethyl)-N6-methyl-2,4,6-pteridinetriamines (1-5) and related N6-substituted 2,4,6-pteridinetriamines (16-20) were obtained by the condensation of 6-chloro-2,4-pteridinediamine with methylarylmethanamine and other selected secondary amines.The requisite N-methylarylmethanamines (21-32) were prepared by the hydrogenation over Pt/C of the corresponding arylcarboxaldehyde in the presence of methanamine.Several of the N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines exhibited exceptional suppressive antimalarial activity against a drug-sensitive line of Plasmodium berghei in mice.N6-Methyl-N6-(1-naphthalenylmethyl)-2,4,6-pteridinetriamine (9), the most active of those compounds, was also shown to be curative at 3.16 mg/kg in a single oral dose against P. cynomolgi in the rhesus monkey.This compound was also shown to be effective against a chloroquine-resistant line of P. berghei in the mouse but showed cross-resistance to a pyrimethamine-resistant strain.Most of the 2,4,6-pteridinetriamines showed strong antibacterial action against Streptococcus faecalis and Staphylococcus aureus.