76562-55-5Relevant articles and documents
Synthesis & Anthelmintic Activity of Some New 1,3-Disubstituted 1,2,3,6-Tetrahydro-2,6-dioxo-8-purinyl Carbamates
Shridhar, D. R.,Rao, K. Srinivasa,Bhopale, K.K.,Tripathi, H. N.,Sai, G. S. T.
, p. 699 - 701 (2007/10/02)
A series of new 1,3-disubstituted 1,2,3,6-tetrahydro-2,6-dioxo-8-purinyl carbamates (VIIa-r) has been synthesized by the condensation of appropriate 5,6-diaminouracils (V) with 1,3-bis(alkoxycarbonyl-S-methyl)isothioureas (VI) and screened for their anthelmintic activity against Nematospiroides dubius, Hymenolepis nana and Ancylostoma ceylanicum.Selected compounds have also been tested for their anthelmintic activity against Nippostrongyles brasiliensis in rats.Three compounds VIIc, VIId and VIIe show moderate antihookworm activity against A. ceylanicum by clearing the worm load by 87, 67 and 58percent respectively at 2*250 mg/kg (p.o.) dose.None of the compounds is found active against N. dubius, H. nana and N. brasiliensis