76562-62-4Relevant academic research and scientific papers
Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents
Isobe, Yoshiaki,Tobe, Masanori,Inoue, Yoshifumi,Isobe, Masakazu,Tsuchiya, Masami,Hayashi, Hideya
, p. 4933 - 4940 (2007/10/03)
In order to create novel, topical anti-inflammatory compounds exhibiting more potent activities than lead compound CX-659S (1), we designed and synthesized various derivatives of 1 focusing on the uracil N(1)- and N(3)-substituents, and evaluated their an
Synthesis & Anthelmintic Activity of Some New 1,3-Disubstituted 1,2,3,6-Tetrahydro-2,6-dioxo-8-purinyl Carbamates
Shridhar, D. R.,Rao, K. Srinivasa,Bhopale, K.K.,Tripathi, H. N.,Sai, G. S. T.
, p. 699 - 701 (2007/10/02)
A series of new 1,3-disubstituted 1,2,3,6-tetrahydro-2,6-dioxo-8-purinyl carbamates (VIIa-r) has been synthesized by the condensation of appropriate 5,6-diaminouracils (V) with 1,3-bis(alkoxycarbonyl-S-methyl)isothioureas (VI) and screened for their anthelmintic activity against Nematospiroides dubius, Hymenolepis nana and Ancylostoma ceylanicum.Selected compounds have also been tested for their anthelmintic activity against Nippostrongyles brasiliensis in rats.Three compounds VIIc, VIId and VIIe show moderate antihookworm activity against A. ceylanicum by clearing the worm load by 87, 67 and 58percent respectively at 2*250 mg/kg (p.o.) dose.None of the compounds is found active against N. dubius, H. nana and N. brasiliensis
