76562-66-8

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-(4-methylphenyl)-
• CAS NO: 76562-66-8
• Molecular Formula: C12H14N4O2
• Molecular Weight: 246.269
• Mol File: 76562-66-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-(4-methylphenyl)-(76562-66-8)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-(4-methylphenyl)-(76562-66-8)

Safety Data

• Hazardous Substances Data: 76562-66-8(Hazardous Substances Data)

Upstream product

• 53681-52-0 C₁₂H₁₃N₃O₂ 
• 19873-46-2 N-Methyl-N'-(4-tolyl)harnstoff 

Downstream Products

• 76562-51-1 (1-Methyl-2,6-dioxo-3-p-tolyl-2,3,6,9-tetrahydro-1H-purin-8-yl)-carbamic acid ethyl ester 
• 176379-51-4 8-(3,5-di-tert-butyl-4-hydroxyphenyl)-1-methyl-3-(4-methylphenyl)purine-2,6-dione 
• 76562-50-0 (1-Methyl-2,6-dioxo-3-p-tolyl-2,3,6,9-tetrahydro-1H-purin-8-yl)-carbamic acid methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases

We have designed and efficiently synthesized novel 1-phenyl-6-aminouracils by replacing the chroman moiety in CX-659S, a nonsteroidal dermatologic candidate, with dimethyldihydrobenzofuranol to cancel CX-659S asymmetric center. Medicinal chemistry effort culminated in the discovery of 13d bearing a 3-methyl group at the 1-phenyl group as a promising compound. Compound 13d, having good in vitro ADME profile and moderate oral bioavailability in mice, showed potent anti-inflammatory activity against hapten-induced contact hypersensitivity reaction in mice following topical and oral administration. The effects of 13d were equipotent to that of tacrolimus or prednisolone. In addition, compound 13d, having potent hydroxyl radical-scavenging activity, showed more potent suppressive effect on substance P-induced pruritus in mice than oxatomide.