76570-24-6Relevant academic research and scientific papers
Heterocyclic compound and organic electroluminescence device including the same
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Paragraph 0199; 0200; 0203; 0204, (2019/02/21)
Provided is a heterocyclic compound represented by Formula 1 below, and an organic electroluminescence device including the same in an emission layer. In Formula 1, X is a direct linkage or CR2R3 , Z1to Z8 are each independently CR4 or N, at least two of
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling
Trist, Iuni M. L.,Nannetti, Giulio,Tintori, Cristina,Fallacara, Anna Lucia,Deodato, Davide,Mercorelli, Beatrice,Palù, Giorgio,Wijtmans, Maikel,Gospodova, Tzveta,Edink, Ewald,Verheij, Mark,De Esch, Iwan,Viteva, Lilia,Loregian, Arianna,Botta, Maurizio
, p. 2688 - 2703 (2016/04/10)
Influenza is an infectious disease that represents an important public health burden, with high impact on the global morbidity, mortality, and economy. The poor protection and the need of annual updating of the anti-influenza vaccine, added to the rapid emergence of viral strains resistant to current therapy make the need for antiviral drugs with novel mechanisms of action compelling. In this regard, the viral RNA polymerase is an attractive target that allows the design of selective compounds with reduced risk of resistance. In previous studies we showed that the inhibition of the polymerase acidic protein-basic protein 1 (PA-PB1) interaction is a promising strategy for the development of anti-influenza agents. Starting from the previously identified 3-cyano-4,6-diphenyl-pyridines, we chemically modified this scaffold and explored its structure-activity relationships. Noncytotoxic compounds with both the ability of disrupting the PA-PB1 interaction and antiviral activity were identified, and their mechanism of target binding was clarified with molecular modeling simulations.
N-Oxides and Related Compounds. Part 60. Novel Thermal and Photochemical Rearrangements of N-Substituted 2-Pyridones
Katritzky, Alan R.,Chapman, Andrew V.,Cook, Michael J.,Millet, George H.
, p. 2743 - 2754 (2007/10/02)
Examples of four novel rearrangements of derivatives of 1-hydroxy-4,6-diphenyl-2-pyridone are reported: all involve N-O fission and formation of 3-substituted or both 3- and 5-substituted-4,6-diphenyl-2-pyridones. (a) 1-OCH2CH2R (R = vinyl or phenyl) compounds give 3-CH2R (R = vinyl or phenyl) derivatives with elimination of CH2O. (b) The 1-octyloxy-compound gives the 3-octyloxy-derivative by simple transposition. (c) 1-Acyloxy-compounds form the corresponding 3- and 5-acyloxy-2-pyridones. (d) 1-Imidoyloxy-compounds yield the rearranged 3- and 5-amido-2-pyridones.The mechanisms probably all involve homolytic N-O fission.
