76570-59-7

Basic information

• Product Name: 4-methyl-2-(methylamino)phenol
• Synonyms: 4-methyl-2-(methylamino)phenol
• CAS NO: 76570-59-7
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.17904
• Mol File: 76570-59-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methyl-2-(methylamino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-(methylamino)phenol(76570-59-7)
• EPA Substance Registry System: 4-methyl-2-(methylamino)phenol(76570-59-7)

Safety Data

• Hazardous Substances Data: 76570-59-7(Hazardous Substances Data)

Upstream product

• 95-84-1 3-amino-4-hydroxytoluene 
• 74-88-4 methyl iodide 
• 17485-25-5 3-methyl-N-nitroso-N-methylaniline 
• 88882-28-4 3,5-dimethylbenzo[d]oxazol-2(3H)-one 
• 75-93-4 methyl bisulfate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 113893-85-9 6-(3-Chlorbenzoyloxymethyl)-3,4-dihydro-4-methyl-2H-1,4-benzoxazin-2-carbonitril 
• 76570-60-0 2-(N-acetyl-N-methylamino)-4-methylphenol 

Relevant articles and documents

Controllable synthesis of 2- And 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols

We present herein a method for the controllable synthesis of 3-aryl-benzomorpholine and 2-aryl-benzomorpholine cycloadducts via cross-coupling/annulation between electron-rich 2-aminophenols and 4-vinylphenols. Molecular oxygen was successfully used in the reaction as the terminal oxidant and the complete inversion of chemoselectivity was achieved by the adjustment of the solvents and bases at room temperature.

N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS

The present invention relates to new antagonists of the interaction between the CCR1 Chemokine receptor and its ligands, including MIP-1α (CCL3), in particular new N-amide derivatives of 8-azabicyclo[3.2.1]oct-3-yl of formula (I).

Studies on the Preparation of N-Alkyl-O-phenylhydroxylamines

Several possible routes to the title compounds have been investigated.The reaction of N-hydroxycarbamates (1) with diphenyliodonium bromide gave, unexpectedly, N-hydroxy-N-phenylcarbamates (2), while N-methyl-N-hydroxycarbamates (6) gave 2-(N-methyl-N-alkoxycarbonylamino)phenols (7).Mechanistic aspects of the N-arylations and subsequent rearrangements are discussed.The desired N-alkyl-O-phenylhydroxylamines were obtained by the reduction of O-phenyloximes (15) with sodium cyanoborohydride.