76572-74-2Relevant academic research and scientific papers
Synthesis and in vitro anti-toxoplasma gondii activity of novel thiazolidin-4-one derivatives
Trotsko, Nazar,Bekier, Adrian,Paneth, Agata,Wujec, Monika,Dzitko, Katarzyna
, (2019/09/04)
Recent findings on the biological activity of thiazolidin-4-ones and taking into account the lack of effective drugs used in the treatment of toxoplasmosis, their numerous side effects, as well as the problem of drug resistance of parasites prompted us to
One-pot two-step facile synthesis of 2,3,4,5-tetra substituted dihydrooxazoles and their antimicrobial activity
Tiwari, Shailendra,Pathak, Poonam,Pratap Singh, Kamal,Sagar, Ram
supporting information, p. 3802 - 3805 (2017/07/27)
New 2,3,4,5-tetra substituted dihydrooxazoles derivatives were efficiently synthesized starting from benzaldehyde, aryl thiosemicarbazide and benzoin using designed synthetic route. Newly synthesized 2,3,4,5-tetra substituted dihydrooxazole derivatives we
Phenolic thio- and selenosemicarbazones as multi-target drugs
Calcatierra, Verónica,López, óscar,Fernández-Bola?os, José G.,Plata, Gabriela B.,Padrón, José M.
, p. 63 - 72 (2015/03/14)
A series of isosteric phenolic thio- and selenosemicarbazones have been obtained by condensation of naturally-occurring phenolic aldehydes and thio(seleno)semicarbazides. Title compounds were designed as potential multi-target drugs, and a series of struc
Inhibition of xanthine oxidase by thiosemicarbazones, hydrazones and dithiocarbazates derived from hydroxy-substituted benzaldehydes
Leigh, Maria,Raines, Daniel J.,Castillo, Carmen E.,Duhme-Klair, Anne K.
experimental part, p. 1107 - 1118 (2012/01/03)
Nonpurine xanthine oxidoreductase (XOR) inhibitors represent important alternatives to the purine analogue allopurinol, which is still the most widely used drug in the treatment of conditions associated with elevated uric acid levels in the blood. By cond
Synthesis and Ribonucleotide reductase inhibitory activity of thiosemicarbazones
Krishnan, Kesavan,Prathiba, Kumari,Jayaprakash, Venkatesan,Basu, Arijit,Mishra, Nibha,Zhou, Bingsen,Hu, Shuya,Yen, Yun
supporting information; experimental part, p. 6248 - 6250 (2009/08/07)
Ribonucleotide reductase (RR) is an important therapeutic target for anticancer drugs. The structure of human RR features a 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2. Prokaryotically expressed and highly purified recombinant human RR subunits, hRRM1 and hRRM2, were used for holoenzyme-based [3H]CDP reduction in vitro assay. Ten new thiosemicarbazones (7-16) were synthesized and screened for their RR inhibitory activity. Two thiosemicarbazones derived from p-hydroxy benzaldehyde (9 and 10) were found to be active but less potent than the standard, Hydroxyurea (HU). Guided by the activity of compounds 9 and 10, 11 new thiosemicarbazones (17-27) derived from p-hydroxy benzaldehyde were prepared and screened for their RR inhibitory activity. All the 11 compounds were more potent than HU.
