76574-50-0

Basic information

• Product Name: 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE
• Synonyms: 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE
• CAS NO: 76574-50-0
• Molecular Formula: C₆H₄F₃N₃O
• Molecular Weight: 191.1106696
• Mol File: 76574-50-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE(76574-50-0)
• EPA Substance Registry System: 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE(76574-50-0)

Safety Data

• Hazardous Substances Data: 76574-50-0(Hazardous Substances Data)

Upstream product

• 943-25-9 2-trifluoromethyl-5-cyano-6-aminopyrimidine 

Downstream Products

• 76575-02-5 6-(2,6-Dichloro-phenyl)-2-trifluoromethyl-pyrido[2,3-d]pyrimidin-7-ylamine 

Relevant articles and documents

Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives

A series of 51 6-arylpyridopyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat.A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyridopyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg.Normalized blood pressure levels could then be maintained by single daily oral doses.The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.