765916-70-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Acetyl-2-fluorophenylboronic acid, pinacol ester is used as a reagent in organic synthesis for the preparation of pharmaceuticals. Its unique structural features make it a valuable tool in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Acetyl-2-fluorophenylboronic acid, pinacol ester is utilized as a reagent for the synthesis of agrochemicals. Its ability to act as a versatile building block contributes to the development of innovative and effective agrochemical products.
Used in Materials Science:
5-Acetyl-2-fluorophenylboronic acid, pinacol ester is employed in materials science for the synthesis of advanced materials. Its unique properties and reactivity make it a key component in the development of new materials with specific properties and applications.
Used in Chemical Research and Drug Discovery:
As a valuable tool in the field of chemical research and drug discovery, 5-Acetyl-2-fluorophenylboronic acid, pinacol ester is used for the exploration of new chemical reactions and the synthesis of novel compounds. Its versatility and reactivity contribute to the advancement of scientific knowledge and the discovery of new drugs and materials.

Upstream product

• 1007-15-4 4-fluoro-3-bromoacetophenone 
• 73183-34-3 bis(pinacol)diborane 

Relevant academic research and scientific papers

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

A tandem cross-coupling/SNAr approach to functionalized carbazoles

(Chemical Equation Presented) A novel route to functionalized carbazoles utilizing a tandem Suzuki cross-coupling/SNAr protocol is described. This process was found to be compatible with a variety of electron-withdrawing groups including aldehy

5-Phenyl[1,2,4]triazines as ligands for GABA-A alpha2/alpha3 receptors for treating anxiety or depression

The present invention provides a compound of formula I, or an N-oxide thereof or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2 represents hydrogen or halogen; Z represents hydrogen, halogen, cyano, cyanomethyl, trifluoromethyl, nitro, hydroxy, hydroxy(C1-6)alkyl, C1-6 alkoxy, C1-6 alkoxy(C1-6)alkyl, trifluoromethoxy, trifluoromethylthio, trifluoromethanesulfinyl, formyl, C2-6 alkoxycarbonyl, oxopyrrolidinyl, or an optionally substituted aryl, heteroaryl or heteroaryl(C1-6)alkoxy group; and R1 represents aryl or heteroaryl, either of which groups may be optionally substituted; pharmaceutical compositions comprising it, its use in therapy and methods of treatment of anxiety and/or depression using it.