76593-36-7

Usage

Uses

3-Amino-6-chloro-4,5-dimethylpyridazine (cas# 76593-36-7) is a useful research chemical.

Upstream product

• 34584-69-5 3,6-dichloro-4,5-dimethylpyridazine 
• 23130-84-9 3-chloro-6-hydrazinyl-4,5-dimethylpyridazine 

Downstream Products

• 51519-08-5 N'-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-N,N-dimethyl-formamidine 
• 152537-58-1 7,8-dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)[1,2,4]triazolo[1,5-b]pyridazine 
• 1105714-18-8 2-(4-fluorophenyl)-6-(4-isopropylpiperazin-1-yl)-7,8-dimethyl-3-pyridazin-4-yl-imidazo[1,2-b]pyridazine 
• 1105714-47-3 ethyl 4-[6-chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate 
• 1105714-48-4 6-chloro-2-(4-fluorophenyl)-7,8-dimethyl-3-pyridazin-4-ylimidazo[1,2-b]pyridazine 
• 1402608-52-9 1-[4-(6-ethoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine 
• 1402608-51-8 1-{4-[7,8-dimethyl-6-(methylsulfanyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutanamine 
• 1402608-50-7 1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine 
• 1402608-49-4 2-[4-(1-aminocyclobutyl)phenyl]-7,8-dimethyl-3-phenylimidazo[1,2-b]-pyridazine-6-carboxamide 
• 1402608-48-3 methyl 2-[4-(1-aminocyclobutyl)phenyl]-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazine-6-carboxylate 
• 1402609-44-2 tert-butyl {1-[4-(6-ethoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]-pyridazin-2-yl)phenyl]cyclobutyl}carbamate 
• 1402609-43-1 tert-butyl (1-{4-[7,8-dimethyl-6-(methylsulfanyl)-3-phenyl-imidazo[1,2-b]pyridazin-2-yl]phenyl}cyclobutyl)carbamate 
• 1402609-41-9 tert-butyl {1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]-pyridazin-2-yl)phenyl]cyclobutyl}carbamate 
• 1402609-42-0 4,5-dimethyl-6-(methylsulfanyl)pyridazin-3-amine 

Relevant academic research and scientific papers

Synthesis and SAR of a new series of COX-2-selective inhibitors: Pyrazolo[1,5-α]pyrimidines

The synthesis and pharmacological activity of a series of bicyclic pyrazolo[1,5-α]pyrimidines as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in human whole blood) and in vivo (carrageenan-induced paw edema and air-pouch model). Modification of the pyrimidine substituents showed that 6,7-disubstitution provided the best activity and led to the identification of 3-(4-fluorophenyl)-6,7-dimethyl-2-(4-methylsulfonylphenyl) pyrazolo[1,5-α]pyrimidine (10f) as one of the most potent and selective COX-2 inhibitor in this series.

N-heterocyclyl sulphonamide derivatives and their use as endothelin antagonists

The invention concerns pharmaceutically useful N-heterocyclyl sulphonamide derivatives, their pharmaceutically acceptable salts, processes for their manufacture, their use for antagonising one or more actions of endothelin in a human or other warm-blooded animal, their use in methods of treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role.